MSNS : R package for Mutli-source nons-specific hybridization model


History

  1. 2009/9/9: Version 0.9.0 Published

Table of Contents

  1. Introduction
  2. Download
  3. Reference

Introduction

This model estimates effects of non-specific hybridization included in observed probe intensity. It assumes that the amounts of cross-hybridization on a probe can be estimated as an ensemble of a diverse of fragments which randomly hybridize with the probe non-specifically. This package provids functions for the estimation of non-specific hybridization and optimization of parameters used in the model.

How to install

For UNIX or MacOSX users

  1. Download the source package.
  2. Open R console, setwd to the directory where the package was placed.
  3. Install package by install.packages as follows,

> install.packages(pkgs="MSNS_0.9.0.tar.gz",repos=NULL,type="source")

For Windows users

  1. Sorry, precombiled package is not available at present. Please try to build from the source.


Download


Reference

[1] C. Furusawa et al., "Model-based analysis of non-specific binding for background correction of high-density oligonucleotide microarrays", (in preparation).
[3] R: A Language and Environment for Statistical Computing, R Development Core Team (2007), Vienna, Austria. ISBN 3-900051-07-0.
[4] Bioconductor, The Bioconductor core team.
[5] GeneChip(R) system, Affymetrix.
Corresponding author: C. Furuswa and N. ONO. ({furusawa,nono} at bio.eng.osaka-u.ac.jp)