大阪大学大学院 情報科学研究科 代謝情報工学講座 清水浩研究室

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二井手 哲平 (Niide Teppei)

 研究領域

・タンパク質工学

・代謝工学

 経歴

2014年 九州大学大学院工学府化学システム工学専攻 博士課程修了

2014年 東北大学大学院工学研究科バイオ工学専攻 博士研究員

2017年 東北大学大学院工学研究科バイオ工学専攻 助教

2019–2020年 ノースカロライナ大学チャペルヒル校 客員研究員

2020年 大阪大学大学院情報科学研究科バイオ情報工学専攻 助教

 原著論文

  1. H. Nakazawa, T. Onodera-Sugano, A. Sugiyama, Y. Tanaka, T. Hattori, T. Niide, H. Ogata, R. Asano, I. Kumagai, M. Umetsu “Association behavior and control of the quality of cancer therapeutic bispecific diabodies expressed in Escherichia coliBiochem. Eng. J., 160 (15), 107636. (2020)
  2. V. Holišová, Z. Konvičcková, G. Kratošová, M. Kolenčcík, T. Niide, M. Umetsu, D. Plachá “Phytosynthesis of Au and Au/ZrO 2 bi-Phasic System Nanoparticles with Evaluation of Their Colloidal Stability” J. Nanosci. Nanotechnol., 19 (5), 2807–2813 (2019)
  3. T. Niide, N. Manabe, H. Nakazawa, K. Akagi, T. Hattori, I. Kumagai, M. Umetsu “Complementary design for pairting between two types of nanoparticles mediated by a bispecific antibody: bottom-up formation of porous materials from nanoparticles” Langmuir, 35 (8), 3067–3076 (2019)
  4. Y. Saito, M. Oikawa, H. Nakazawa, T. Niide, T. Kameda, K. Tsuda, M. Umetsu “Machine-Learning-Guided Mutagenesis for Directed Evolution of Fluorescent Proteins” ACS Synth. Biol., 7 (9), 2014–2022 (2018)
  5. H. Fujii, Y. Tanaka, H. Nakazawa, A. Sugiyama, N. Manabe, A. Shinoda, N. Shimizu, T. Hattori, K. Hosokawa, T. Sujino, T. Ito, T. Niide, R. Asano, I. Kumagai, M. Umetsu “Compact Seahorse-Shaped T Cell–Activating Antibody for Cancer Therapy” Adv. Therap. 1, 1700031 (2018)
  6. Z. Konvičková, V. Holišová, M. Kolenčík, T. Niide, G. Kratošová, M. Umetsu J. Seidlerová “Phytosynthesis of colloidal Ag-AgCl nanoparticles mediated by Tilia sp. leachate, evaluation of their behaviour in liquid phase and catalytic properties” Colloid Polym. Sci., 296, 677–687 (2018)
  7. A. Sugiyama, M. Umetsu, H. Nakazawa, T. Niide, R. Asano, T. Hattori, I. Kumagai “High-throughput cytotoxicity and antigen-binding assay for screening small bispecific antibodies without purification” J. Biosci. Bioeng., 17, 31237-31239 (2018)
  8. A. Sugiyama, M. Umetsu, H. Nakazawa, T. Niide, T. Onodera, K. Hosokawa, S. Hattori, R. Asano, I. Kumagai “A semi high-throughput method for screening small bispecific antibodies with high cytotoxicity” Sci. Rep., 7, 2862, 1–12 (2017)
  9. Y. Hosomomi, T. Niide, R. Wakabayashi, M. Goto, N. Kamiya “Biocatalytic formation of gold nanoparticles decorated with functional proteins inside recombinant Escherichia coli cells” Anal. Sci., 32, 295–300 (2016)
  10. T. Niide, K. Ozawa, H. Nakazawa, D. Oliveira, H. Kasai, M. Onodera, R. Asano, I. Kumagai, M. Umetsu “Organic crystal-binding peptide: Morphology control and one-pot formation of protein-displaying organic crystals” Nanoscale, 7, 20155–20163 (2015)
  11. T. Niide, M. Goto, N. Kamiya “Enzymatic self-sacrificial display of an active protein on gold nanoparticles” RSC Adv., 4, 5995–5998 (2014)
  12. T. Niide, K. Shimojo, R. Wakabayashi, M. Goto, N. Kamiya “Enzymatic fabrication of protein-decorated gold nanoparticles by the aid of artificial peptides with gold-binding affinity”, Langmuir, 29, 15596–15605 (2013)
  13. K. Shimojo, T. Niide, T. Taguchi, H. Naganawa, N. Kamiya, M. Goto “Facile, rapid and efficient biofabrication of gold nanoparticles decorated with functional proteins”, Analyst, 137, 2300–2303 (2012)
  14. T. Niide, M. Goto, N. Kamiya “Biocatalytic synthesis of gold nanoparticles with cofactor regeneration in recombinant Escherichia coli cells”, Chem. Chommun., 47, 7350–7352 (2011)
  15. T. Oshima, T. Niide, H. Shiraki, Y. Baba, “Preparation and separation of heme iron preparation from fish blood of cultured yellowtail”, Kagaku Kogaku Ronbunshu, 37, 51–56 (2011)
  16. Y. Shimada, T. Niide, F. Kubota, N. Kamiya, M. Goto, “Selective separation of precious metals using biomass materials”, Kagaku Kogaku Ronbunshu, 36, 255–258 (2010)
  17. T. Niide, H. Shiraki, T. Oshima, Y. Baba, N. Kamiya, M. Goto, “Quaternary ammonium bacterial cellulose for adsorption of proteins”, Solvent Extr. Res. Dev., 17, 73- 81 (2010)

解説

  1. 二井手哲平, 中澤光, 梅津光央 “親水性ペプチド分子による有機結晶の構造制御と生体分子-半導体有機結晶ハイブリッド材料作製プロセスの開発” ケミカルエンジニヤリング 62(7), 23-27, 2017年7月
  2. 梅津光央, 中澤光, 二井手哲平 “構造情報を取り入れた進化工学アプローチによる分子認識タンパク質の設計” MEDCHEM NEWS, 27(1), 25-29, 2017年2月

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